Eurasian Chemical Communications

Evaluation of the adrenomedullin, ferritin and some biochemical parameters in type 2 diabetes patients

Arwa Muhammad Hashem; Abdulmonaim Hamad Majied Al-Samarrai; Othman Rashid Al Samarrai

Volume 4, Issue 7 , July 2022, , Pages 636-644

https://doi.org/10.22034/ecc.2022.332813.1357

Abstract

Diabetes mellitus is a clinical syndrome characterized by a high level of glucose in the blood resulting from a defect in insulin secretion or insulin action or both, which causes an ... Read More Diabetes mellitus is a clinical syndrome characterized by a high level of glucose in the blood resulting from a defect in insulin secretion or insulin action or both, which causes an imbalance of glucose utilization in tissues and glucose release by the liver. A biochemical study was conducted to assess the level of adrenomedullin and some biochemical variables had 140 blood samples for men, including four groups per group 35 samples, (G1) group 2 DM, (G2) 2 DM with hypertension, DM(G3)2 with renal failure and the control group. Their ages range between 30-70 years. Patient samples were collected from Samarra General Hospital and outpatient clinics between 20/12/2020 to 20/4/2021. The current study approached the evaluation of the concentration of adrenomedullin, ferritin, glucose, urea, creatinine, glutathione and malondialdehyde, Hba1c. The results showed a significant increase (P≤0.05) in the level of adrenomedullin in G1, with a decrease in G2 and G3 compared with the control group, and the level of ferritin increased significantly in G1, G2 and G3 compared with the control group, while the results indicated a significant decrease in the level of GSH in G1, G2, and G3 compared with the control group. The level of MDA significantly increased in G1, G2 and G3 compared with the control group. Further, the level of glucose significantly increased in G1, G2 and G3 compared with the control group, and the concentration of Hba1c increased significantly in G1 and G2, while G3 did not show any significant differences compared with the control group. The level of urea increased significantly in G2 and G3, while G1 did not show any significant differences compared with the group. And creatinine level increased significantly in G3, while G1 and G2 did not show any significant differences in comparison to the control group. From the current study, we concluded that diabetes, hypertension, and kidney disease had a clear effect on biochemical parameters and increased oxidative stress.

Eurasian Chemical Communications

Articles in Press

Current Issue

Volume 5 (2023)

Volume 4 (2022)

Volume 3 (2021)

Volume 2 (2020)

Volume 1 (2019)

Author = Abdulmonaim Hamad Majied Al-Samarrai

Evaluation of the adrenomedullin, ferritin and some biochemical parameters in type 2 diabetes patients

Abstract