Pharmaceutical Chemistry
Sevil Mehraliyeva; Mahbuba Valiyeva; Nijat Abbasli; Tarana Suleymanova; Sevinj Musayeva; Soodabeh Davaran; Rovshan Khalilov; Aziz Eftekhari
Abstract
This study focuses on obtaining an extract from clove and calendula plants with colloidal nanoparticles of silver in the presence of 40% propyleneglycol and preparation of hydrophilic gel based on the resulting extract. Also, the optimal composition of the gel and releasing of biologically active substances ...
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This study focuses on obtaining an extract from clove and calendula plants with colloidal nanoparticles of silver in the presence of 40% propyleneglycol and preparation of hydrophilic gel based on the resulting extract. Also, the optimal composition of the gel and releasing of biologically active substances from gels based on chitosan, sodium carboxymethylcellulose, carbopol, used as gelling agents was evaluated. The results showed that the release of bioactive compounds from a chitosan-based gel is more complete and intensive. The antibacterial and antifungal properties of chitosan gel containing silver nanoparticles have been confirmed by microbiological studies.
Pharmaceutical Chemistry
Arash Larki; Nader Shakiba Maram; Amanollah Zarei Ahmady; Neda Mohtasham; Ladan Mafakher; Nooshin Khelghati; Ehsan Hedayati
Abstract
The fruit of Cordia myxa (C. myxa) is widely used for the treatment of respiratory and urinary infections, and as a diuretic, astringent, demulcent and expectorant agent. Other pharmacological effects such as anti-inflammatory, antibacterial, antiviral, anti-allergic, antitumor and antioxidants activity ...
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The fruit of Cordia myxa (C. myxa) is widely used for the treatment of respiratory and urinary infections, and as a diuretic, astringent, demulcent and expectorant agent. Other pharmacological effects such as anti-inflammatory, antibacterial, antiviral, anti-allergic, antitumor and antioxidants activity have also been reported for C. myxa by other studies. This study aimed to compare different extraction methods and offer a way to produce an easy-to-use formulation. In this study, extracts from the fresh and dried fruits of C. myxa were obtained using four extraction methods including soxhlet, maceration, percolation and digestion. Extraction from the dried fruits showed better results compared with that of the fresh fruits. Also, the soxhlet method of extraction using dry powdered fruits was the most efficient for extraction of active components of C. myxa fruits. Preliminary phytochemical screening showed the aqueous extract of fruits to be full of active ingredients such as alkaloids, flavonoids, tannins, phenolic compounds, Steroids, carbohydrates, and saponins. Finally, an oral syrup formulation from C. myxa fruits extract was prepared for the first time and its physicochemical properties such as light transmittance, visual inspection, pH measurement, sucrose concentration, viscosity, and antimicrobial tests were evaluated. The applied method is a quite easy, simple, environmental friendly and convenient way for extraction and oral syrup preparation of C. myxa fruits.
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