@article { author = {Al-Haidari, Akram S. and Al-Tamimi, Entesar O.}, title = {Synthesis of new derivatives of 1,3,4-thiadiazole and 1,3,4-oxadiazole on cyclic imides and studying their antioxidant}, journal = {Eurasian Chemical Communications}, volume = {3}, number = {7}, pages = {508-517}, year = {2021}, publisher = {Sami Publishing Company (SPC)}, issn = {2717-0535}, eissn = {2676-6280}, doi = {10.22034/ecc.2021.289788.1185}, abstract = {The research resulted in the production of new thiadiazole derivatives and oxadiazole derivatives via the reaction of cyclic imides with chloro acetyl chloride at heat condition to give N-acetyl chloro cyclic imides (1,2). Then react these compounds (1,2) with hydrazine hydrate to give N-(aceto hydrazide) cyclic imides (3,4). Then, compounds (3,4) go into three routes: route one was reacting with CS2 in the presence of (KOH) in ethanol at (24 hrs.) to give (N-[(2-thio-1,3,4-thiadiazolo-5-yl) methylene] cyclic imides) (5,6). Route two was reacting using various aromatic carboxylic acids in the presence of (POCl3) to give (N- [{2-(subs. benzene)-1,3,4-oxadiazolo-5-yl. methylene] cyclic imides) (7-14). Route three was reacting with ammonium thiocyanate in the presence of HCl in ethanol for (5 hrs.), followed cyclization in the presence of concentration (H2SO4) to give (N-[(2-amino-1,3,4-thiadiazolo-5-yl) methylene] cyclic imides) (15,16). Prepared compounds have been characterized by FTIR, and some of them by 1H-NMR, melting point, and were studied the effects of the preparing compounds on antioxidant.}, keywords = {cyclic imides,Thiadiazole,oxadiazole,Antioxidant}, url = {https://www.echemcom.com/article_132903.html}, eprint = {https://www.echemcom.com/article_132903_60622aef7c405cd74989fb26c0a20219.pdf} }