@article { author = {Sallal, Zainab and Al-Tamimi, Entesar}, title = {Modification and characterization of subs. triazole on creatinine and studying their antioxidant activity}, journal = {Eurasian Chemical Communications}, volume = {4}, number = {2}, pages = {152-159}, year = {2022}, publisher = {Sami Publishing Company (SPC)}, issn = {2717-0535}, eissn = {2676-6280}, doi = {10.22034/ecc.2022.320360.1280}, abstract = {In this work, new creatinine derivatives containing (1,2,4-triazole and 5-subs-1,2,4-triazole) ring have been prepared. In the first step, creatinine was reacted with different acid chloride to form 2-subs. amido creatinine 1[a-d]. In the second step, amido creatinine 1[a-d] was reacted with succinoyl chloride to produce imide derivatives 2[a-d]. In the third step, the imide componds prepared were reacted with hydrazine hydrate to give acid hydrazide derivatives 3(a-d). Finally, 1,2,4-triazole derivatives 4-7[a-d] were prepared from the reaction between acid hydrazide with different amide compounds by pellizzari reaction. These new synthesized products have been characterized by FT-IR, 1H-NMR for some of them and were studied regarding the effect of preparing derivatives on antioxidant.}, keywords = {Creatinine,Imide,acid hydrazide,1,2,4-Triazole,Antioxidant activity}, url = {https://www.echemcom.com/article_143425.html}, eprint = {https://www.echemcom.com/article_143425_5b059cb36af028515b9f705e1db07615.pdf} }