@article { author = {Juhi, Ali and Abdul_Razaq, Aliaa}, title = {Evaluation of ZBTB40 Rs6426749, BMD and BMI in Iraqi women with osteoporosis}, journal = {Eurasian Chemical Communications}, volume = {4}, number = {5}, pages = {372-386}, year = {2022}, publisher = {Sami Publishing Company (SPC)}, issn = {2717-0535}, eissn = {2676-6280}, doi = {10.22034/ecc.2022.325419.1310}, abstract = {Varieties within the genomic region of 1p36.12 have already been linked with osteoporosis in genome-wide association studies (GWASs), even though the functional implications behind these non-coding variants remain uncertain. We highlighted rs6426749 as a probable causative variant for osteon at 1p36.12 predicated on comprehensive genomic analyses and epigenetic evaluations. For sampling, fifty (50) patients with osteoporosis were admitted to Baghdad Teaching Hospital, and 40 healthy subjects were performed in Baghdad Teaching Hospital/Bone Density Screening Unit/ Baghdad - Iraq between September 2020 January 2021. We used nested PCR of the Genome-wide association studies of the primers designed by the primer3 program. For rs6426749 G/C genotyping, The results of osteoporosis patients (women) and the healthy group was studied according to bone mineral density. The results showed a significant difference between the two study groups in bone mineral density and body mass index. The mean of patient groups was mean±SD (0.6824±0.08285), and control groups were mean±SD (1.066±0.06876). Then we divided the patients into three groups according to their age, and from the age of 30 to 44, they were called pre-menopause, from the age of 45 to 55, they were called Menopause, and from the age of 56 to 70, they were called Post menopause, and we compared these three groups with the control. The results showed that there was statistically significant P-Value <0.0001 differences.}, keywords = {Osteoporosis,BMD,BMI}, url = {https://www.echemcom.com/article_145417.html}, eprint = {https://www.echemcom.com/article_145417_ebc86720cc7f79dab1e18755af5e42d8.pdf} }