%0 Journal Article %T Beneficial effects of nano-phytosome of Quercetin on inflammatory parameters in mouse model of multiple sclerosis %J Eurasian Chemical Communications %I Sami Publishing Company (SPC) %Z 2717-0535 %A Saadat, Maryam %A Malekloo, Roya %A Davoodi, Marzieh %A Sadat Afraz, Elham %A Vaez, Aysan %A Asadi, Ilia %A Falahati, Ali Mohammad %A Safarbalou, Asal %A Moradi-kor, Nasrollah %D 2022 %\ 05/01/2022 %V 4 %N 5 %P 432-440 %! Beneficial effects of nano-phytosome of Quercetin on inflammatory parameters in mouse model of multiple sclerosis %K Cytokines %K Quercetin %K Nano-Phytosome %K Mice %K TNF-α %R 10.22034/ecc.2022.331138.1335 %X This study evaluated the beneficial effects of quercetin nano-phytosome on inflammatory parameters in multiple sclerosis. The animals were divided into five groups, including Control, 150 Quercetin, 300 Quercetin, 150 and 300 nano-phytosome of Quercetin. At the end of the study, serum levels of Granulocyte-macrophage colony stimulator (GMCSF), interleukin 1β (IL1β), interleukin 2 (IL2), interleukin 6 (IL6), interleukin 10 (IL10), interleukin 17 (IL17), Interleukin gamma (IFNγ) and tumor necrosis factor alpha (TNFα) were determined. The results showed that administration of Quercetin and its nano-phytsome significantly decreased the levels of IL-1β, IL-2, IL-6, IL-17, IFN-γ, TNF-α and GM-CSF and increased IL-10 in comparison to the control group. The treated animals with nano-phytsome significantly decreased IL-2, IL-1β, IL-17, IL-6, IFN-γ, TNF-α and GM-CSF and increased IL-10 compared with Quercetin group. Quercetin nanophytosomes can be used to effectively improve inflammation. We recommend using quercetin nanophytosomes to reduce inflammation in patients with multiple sclerosis. %U https://www.echemcom.com/article_146320_ccc441764429d2dffbbb91b545ac630e.pdf