%0 Journal Article %T New fused-coumarin composites: synthesis, anticancer and antioxidant potentials evaluation %J Eurasian Chemical Communications %I Sami Publishing Company (SPC) %Z 2717-0535 %A Jasim, Sara Firas %A Mustafa, Yasser Fakri %D 2022 %\ 07/01/2022 %V 4 %N 7 %P 607-619 %! New fused-coumarin composites: synthesis, anticancer and antioxidant potentials evaluation %K Coumarin composites %K Anticancer %K Antioxidant %K ADME %K Normal cells %R 10.22034/ecc.2022.335450.1392 %X Today, there is a pressing need to develop anti-carcinogenic and anti-oxidative agents with the improved potency and fewer side effects. To this end, new coumarin composites were prepared through the Pechmann condensation reaction. The skeletal formulas of the prepared composites were elucidated via well-known spectroscopical methods, whereas the pharmacokinetics and drug-likeness of them were analyzed by the ADME study. The MTT-based test was employed to estimate the effect of the prepared coumarin composites as neoplastic inhibitory agents in-vitro towards six cancerous-cell lines involving AMN3, SKG, KYSE-30, HeLa, SK-OV-3, and MCF-7. Additionally, the previous test was utilized to inspect the safety of the prepared composites towards a normal human-cell line. Likewise, the prepared coumarin composites’ anti-oxidative effect was investigated in-vitro by utilizing DPPH and hydroxide radical moieties. The findings unveiled that the composite with the powerful electronegative substituent, SF4, had an eminent neoplastic inhibitory effect among other composites, with IC50 values close to the gold standard (5-fluorouracil), specifically towards HeLa and MCF-7 cells. Concerning safety, when compared with the standard, the prepared coumarin composites had a higher safety level on the inspected normal-cell line. Among them, the composite SF4 had the highest safety rating. Moreover, composite SF0 demonstrated a remarkable antioxidative effect on the inspected free radical moieties, with TC50 values near the standard (cevitamic acid). Also, most prepared composites had appropriate hypothetical pharmacokinetics and drug-likeness based on the ADME analysis, indicating that they could be used by the oral route. %U https://www.echemcom.com/article_147418_1157fdbd1cd0c35b49c9f983a6430800.pdf