%0 Journal Article %T Assessment of hypoxemia status by measuring serum level of hypoxia inducible factor 1 alpha in relation to tumor suppression protein p53, estradiol and tumor proliferation markers of breast cancer in Thi-Qar province/Iraq %J Eurasian Chemical Communications %I Sami Publishing Company (SPC) %Z 2717-0535 %A Khadem, Zainab Ali %A AL-Shammaree, Shatha Abdul Wadood %A Abdulretha, Mohanad %D 2022 %\ 07/01/2022 %V 4 %N 7 %P 625-635 %! Assessment of hypoxemia status by measuring serum level of hypoxia inducible factor 1 alpha in relation to tumor suppression protein p53, estradiol and tumor proliferation markers of breast cancer in Thi-Qar province/Iraq %K hypoxia %K breast cancer %K invasive ductal carcinoma %K HIF-1α, tumor suppression protein p53 %K estradiol and lymph node metastases %R 10.22034/ecc.2022.328706.1321 %X Hypoxemia means low levels of oxygen in the blood and it alters cancer cell metabolism and causes multiple intracellular signaling pathways. Investigate hypoxia status by measuring the concentration of HIF-1α as a prognostic factor of hypoxia and its relation to tumor suppressor protein p53, estradiol, tumor grade, tumor size, and lymph node metastases of adult female with breast cancer. This study is a case control study which includes sixty- five adult female patients with breast mass. Out of 65 patients, a 44 (68%) were with fibroadenoma in the age range of 18-42 (32.55±6.40) and the other 21 (32%) cases with breast cancer type invasive ductal carcinoma (IDC) aged 32-80 (56± 14.4). Most IDC cases were in grade III and sizes T2 and T3. The other 50 healthy females, as a control group were in mean age of 44.56±16.85. Preoperative blood samples were collected for biochemical analysis by the ELISA method. A significant elevation in serum HIF-1α, P53 and E2 (p<0.001) in IDC cases as compared to fibroadenoma and the control group, there was a positive relation between HIF-1α, P53, and E2. HIF-1 α, P53, and E2 were significantly elevated in the patients with grade III and tumor stage T3 than grade II and stages T2 and T1. A significant elevation was found in the subgroup of positive LNM for all preoperative serum levels of parameters compared with the negative LNM patients group. HIF-1α, p53, and E2 were useful markers of invasion depth of tumor or LNM in breast cancer staging and the interactions between HIF-1α, p53, and E2 signaling pathways may be of major clinical significance in cancer therapies through targeting the lowering of severity of hypoxia and angiogenesis. %U https://www.echemcom.com/article_147905_ec85292807bb8be983f504698f64c374.pdf