Sami Publishing Company (SPC)
Eurasian Chemical Communications
2717-0535
2676-6280
3
7
2021
07
01
Role of pyridazine analogs as acetylcholinesterase inhibitor: An approach for management of alzheimer’s disease
435
442
EN
Saad
Alghamdi
0000-0003-4532-9128
Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, 21955, Saudi Arabia
saadsn@gmail.com
Mohammad
Asif
0000-0002-9352-3462
Glocal School of Pharmacy, Glocal University, Mirzapur Pole, Saharanpur, Uttar Pradesh, India
aasif321@gmail.com
10.22034/ecc.2021.229705.1168
Alzheimer's disease (AD) is a neurodegenerative disorder causing failure of cognitive aptitude and performance irregularities, resulting in degradation of cerebral and psychological activities. AD is presently a main health trouble and it is the third-major reason of casualty in the developed nations after cardiac and cancer diseases. The physiological pathway of this disorder remains almost unknown. The present curative advances to AD pursue the cholinergic theory. The acetylcholinesterase (AChE) enzyme has an essential role in the therapy of AD. The AChE-inhibitors have been developed into the leading approach for the advance of anti-ADs. Some AChE-inhibitors, like donepezil, tacrine, rivastigmine and ensaculin have shown progress in memory and cognitive actions. However, ensaculin is a coumarin analog that has prevented or lowered the progressive neurodegeneration. Several considerations support that some pyridazine analogs act as AChE and BuAChE inhibitors.
Acetyl-cholinesterase,Alzheimer's disease,butyryl-cholinesterase,neurodegenerative,pyridazine derivatives
https://www.echemcom.com/article_131392.html
https://www.echemcom.com/article_131392_9f0219b81003057b381fd89a13b4897c.pdf
Sami Publishing Company (SPC)
Eurasian Chemical Communications
2717-0535
2676-6280
3
7
2021
07
01
Effect of magnetic field on the preparation of Cu doped zinc oxide nanostructures in different temperatures
443
451
EN
Haqi
I.
Ahmed
0000-0003-0111-5439
Ministry of Education, Baghdad, Iraq
haqihaqii1985@gmail.com
Nadia
A.
Abdulrahman
Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq
nadia234@gmail.com
10.22034/ecc.2021.282390.1171
We tried to overcome some industrial defects of crystals (Cu doped ZnO) while improving some of its features through the use of three important factors: Doping (5% Cu), temperature, and magnetic field effect. We have identified some of its properties and dimensions through UV, XRD and FE-SEM measurements. We have succeeded in preparing Cu doped ZnO Nanostructure with different lengths and diameters, more uniform crystals, as well as multiple energy gap values. This allows it to be used in a wide range of technology applications. Energy gap values are clearly affected by the increase in temperature and the presence of the magnetic field. The size of the crystals increases with the increase in temperature and the presence of the magnetic field. The crystals become more uniform and the artificial defects decrease. The change in the dimensions of the crystals with increasing temperature depends on the nature of doping and the nature of semiconductor metallurgy. Lengths and diameters of the Nanostructure increase with increasing temperature and with the presence of the magnetic field, which means more attractive and useful features. Enhanced catalytic efficiency of Cu-doped ZnO is attributed to intrinsic oxygen vacancies mainly due to high surface to volume ratio in nanorods and as well as extrinsic defect due to Cu doping. While the method (Cu doped ZnO) demonstrates the half-metallic ground state as well and the high ferromagnetic stability for all the measured Cu concentrations mostly within the generalized gradient approximation.
Nanoscience,Nanoparticles,Magnetic field,Hydrothermal,Cu doped ZnO,Semiconductor,Doping
https://www.echemcom.com/article_131420.html
https://www.echemcom.com/article_131420_5b7111eee2eaa952270fb156da9af9a5.pdf
Sami Publishing Company (SPC)
Eurasian Chemical Communications
2717-0535
2676-6280
3
7
2021
07
01
Shikimic acid from staranise (Illicium verum Hook): Extraction, purification and determination
452
460
EN
Ali
Ramazani
0000-0003-3072-7924
Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan 45371-38791, Iran
aliramazani@gmail.com
Fatemeh
Shahkarami
Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan 45371-38791, Iran
shahkaramifatemeh@yahoo.com
Armin
Zarei
0000-0003-2326-4431
Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan 45371-38791, Iran
zareie.ar@gmail.com
Sobhan
Rezayati
0000-0001-8940-2927
Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan 45371-38791, Iran
sobhan.rezayati@yahoo.com
Aram
Rezaei
Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
aram.rezaei@gmail.com
Ali
Bodaghi
Department of Chemistry, Tuyserkan Branch, Islamic Azad University, Tuyserkan, Iran
alibodaghi@ymail.com
Leila
Youseftabar-Miri
Department of Organic Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
l_youseftabar@yahoo.com
10.22034/ecc.2021.285563.1176
Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) is considered as an essential biochemical metabolite in autotrophic organisms, such as plants and some bacteria, which is used to procreate the anti-influenza drug oseltamivir. Generally speaking, there are three main methods to produce shikimic acid, which are included in the chemical synthesis and microbial fer
Additional information
mentation as well as extraction from natural plants. This review focused on the extraction of shikimic acid from Chinese star anise as the main industrial source for shikimic acid production and presents some of the conducted studies for the extraction of shikimic acid from Chinese star anise and its purification and determination over the last decade.
Shikimic acid,Chinese star anise,Natural plants,Extraction,Traditional Chinese medicine
https://www.echemcom.com/article_131517.html
https://www.echemcom.com/article_131517_d51951b8ba3a6a0191f0388aea431314.pdf
Sami Publishing Company (SPC)
Eurasian Chemical Communications
2717-0535
2676-6280
3
7
2021
07
01
Synthesis of new heterocyclic derivatives from 2-furyl methanethiol and study their applications
461
476
EN
Aqeel
S.
Maged
0000-0003-0111-5434
Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq
akeelsami8888@gmail.com
Luma
S.
َAhamed
0000-0002-6482-6747
Department of chemistry, College of Sciences, University of Baghdad, Baghdad, Iraq
lama.s@sc.uobaghdad.edu.iq
10.22034/ecc.2021.279489.1158
In this research, cyclic compounds derived from 2- furfural mercaptan (oxazole, triazoles) were synthesized, and their biological efficacy was measured and compared with standard drugs. Also, their effectiveness as anti-oxidant was measured and compared with ascorbic acid as a standard substance. Some of the synthesized compounds were deduced with good efficacy.
Heterocyclic,2-furyl methanethiol,ascorbic,Triazole
https://www.echemcom.com/article_131432.html
https://www.echemcom.com/article_131432_c128a00c4aa6800486f7d8193c826baa.pdf
Sami Publishing Company (SPC)
Eurasian Chemical Communications
2717-0535
2676-6280
3
7
2021
07
01
Synthesis of viscosity index improver for motor lubricating oil
477
483
EN
Zaydoon
Kh.
Kuraimid
0000-0000-0000-0000
Petroleum Research and Development Center (PRDC), Ministry of Oil, Baghdad, Iraq
zaydoon05@yahoo.com
Qays
Mothanna
Ammouri
Petroleum Research and Development Center (PRDC), Ministry of Oil, Baghdad, Iraq
zaydoon8905@yahoo.com
Thabit
A.
Ahmed
Petroleum Research and Development Center (PRDC), Ministry of Oil, Baghdad, Iraq
Hadeel
A. Husain
Husain
Petroleum Research and Development Center (PRDC), Ministry of Oil, Baghdad, Iraq
10.22034/ecc.2021.285880.1177
The viscosity of lubrication oil is the important property to evaluate the behavior of lubrication activity of oil. Viscosity index VI is the standard indicator of effecting temperature on viscosity of lubricating oil.<br /> Viscosity index improvers are the chemicals that added to base lubricating oil produced from refineries to make oil stable against temperature elevation during internal combustion engine operation.<br /> In this work, special viscosity index improver was prepared by blending of DQC (that synthesized depending on Ethylene Diamine Tetra Acetic acid original compound) with polyoxyethylene (p <sub>20</sub>) in presence of mystelene as solvent. The prepared viscosity index improver was added to base lubricating oil grade SN-500 produced from Al – Dorah refinery with different weight ratios, adding 7.8% of viscosity index improver to SN-500 base oil improved VI by 14 degrees without effect on other properties of oil.
Polyoxyethylene(p20),mystelene,SN-500,DQC
https://www.echemcom.com/article_132252.html
https://www.echemcom.com/article_132252_19abaf77ea2c93748673a8e19ae462b2.pdf
Sami Publishing Company (SPC)
Eurasian Chemical Communications
2717-0535
2676-6280
3
7
2021
07
01
Important thermodynamic variables with the kinetic study of the stage of industrial oil water treatment via ion-exchange resin
484
494
EN
Zaydoon
Kh.
Kuraimid
0000-0000-0000-0000
Petroleum Research and Development Center (PRDC), Ministry of Oil, Baghdad, Iraq
zaydoon05@yahoo.com
10.22034/ecc.2021.286718.1179
Ion-exchange technology was used in the present work for removing sodium, sulphate, and chloride pollutants from the wastewater of the Daura refinery. Here, the batch experiments were conducted for examining the effects of mixing time and resin amount on the residual of pollutants and removal efficiency in this work. Adsorption kinetics and thermodynamics were also studied. The adsorption was feasible, spontaneous, and endothermic, according to many thermodynamic parameters such as the enthalpy (∆H), free energy (∆G), and entropy (∆S). Chloride, sulfate, and sodium have removal efficiencies of (88, 91, and 82) % respectively. For sodium and sulfate, the best mixing time is 12 minutes, and for chloride, it is 14 minutes. The pseudo-second-order kinetic model fits sulfate adsorption on lewatit well, but the pseudo-first-order kinetic model fits sodium and chloride adsorption on lewatit well.
industrial oil water,lewatit,Enthalpy,Sulfate,Sodium
https://www.echemcom.com/article_132202.html
https://www.echemcom.com/article_132202_4aa96ad75f1ae4927d3c0b883147b22d.pdf
Sami Publishing Company (SPC)
Eurasian Chemical Communications
2717-0535
2676-6280
3
7
2021
07
01
Thermodynamic study and spectrophotometric determination of cefixime trihydrate in pure form and pharmaceutical tablets using batch and normal flow injection analysis
495
507
EN
Hind
Sadiq
Al-warda
000-567-5679-5677
Chemistry Department, College of Sciences, Baghdad University, Baghdad, Iraq
hind.s@sc.uobaghdad.edu.iq
Mohammed
Rifaat
Ahmed
000-567-5679-5670
Chemistry Department, College of Sciences, Baghdad University, Baghdad, Iraq
hind.rs@sc.uobaghdad.edu.iq
Mouayed
Qassim
Al-Abachi
Ashur University college, Emeritus professor at College of Women Sciences, Baghdad University, Baghdad, Iraq
hindd.s@sc.uobaghdad.edu.iq
10.22034/ecc.2021.289383.1183
This study aimed at developing pectrophotometric methods for the determination of Cefixime Trihydrate [CFT] by simple, sensitive batch and flow-injection analysis in its purest form and tablet formulations. These developed methods were based on an oxidative coupling reaction of CFT with thaimine hydrochloride in the presence of a basic medium and using potassium ferricyanuide as an oxidant to produce a stable water-soluble, intense orange dye with a maximum absorption at 440 nm. Beer's law was followed over the concentration range [2.5-75 and 10-400 µg.mL<sup>-1</sup>] of CFT with limits of detection of 0.7223 and 2.6145 µg.mL<sup>-1</sup> of CFT for batch and FIA methods, respectively. The average sample throughput for the FIA was 68 h<sup>-1</sup>. The effects of various chemical and physical experimental parameters on the development and stability of the colored product were carefully investigated. CFT estimated in commercial tablets forms was successfully applied using these methods, in which the results were in good agreement with those produced using the official procedure. Thermodynamic parameters, including the free energy changes [∆G], enthalpy [∆H] and entropy [∆S] were determined at different temperatures for the reaction product.
cefixime trihydrate,thiamine hydrochloride,Thermodynamic,flow injection,Spectrophotometry
https://www.echemcom.com/article_132688.html
https://www.echemcom.com/article_132688_40eef247bb241e4d0cb2c0a124e652f1.pdf
Sami Publishing Company (SPC)
Eurasian Chemical Communications
2717-0535
2676-6280
3
7
2021
07
01
Synthesis of new derivatives of 1,3,4-thiadiazole and 1,3,4-oxadiazole on cyclic imides and studying their antioxidant
508
517
EN
Akram S.
Al-Haidari
Department of Chemistry, College of Science, Baghdad University, Baghdad, Iraq
Entesar O.
Al-Tamimi
Department of Chemistry, College of Science, Baghdad University, Baghdad, Iraq
10.22034/ecc.2021.289788.1185
The research resulted in the production of new thiadiazole derivatives and oxadiazole derivatives via the reaction of cyclic imides with chloro acetyl chloride at heat condition to give N-acetyl chloro cyclic imides (1,2). Then react these compounds (1,2) with hydrazine hydrate to give N-(aceto hydrazide) cyclic imides (3,4). Then, compounds (3,4) go into three routes: route one was reacting with CS<sub>2</sub> in the presence of (KOH) in ethanol at (24 hrs.) to give (N-[(2-thio-1,3,4-thiadiazolo-5-yl) methylene] cyclic imides) (5,6). Route two was reacting using various aromatic carboxylic acids in the presence of (POCl<sub>3</sub>) to give (N- [{2-(subs. benzene)-1,3,4-oxadiazolo-5-yl. methylene] cyclic imides) (7-14). Route three was reacting with ammonium thiocyanate in the presence of HCl in ethanol for (5 hrs.), followed cyclization in the presence of concentration (H<sub>2</sub>SO<sub>4</sub>) to give (N-[(2-amino-1,3,4-thiadiazolo-5-yl) methylene] cyclic imides) (15,16). Prepared compounds have been characterized by FTIR, and some of them by <sup>1</sup>H-NMR, melting point, and were studied the effects of the preparing compounds on antioxidant.
cyclic imides,Thiadiazole,oxadiazole,Antioxidant
https://www.echemcom.com/article_132903.html
https://www.echemcom.com/article_132903_60622aef7c405cd74989fb26c0a20219.pdf