TY - JOUR ID - 105259 TI - Nano-molar level determination of isoprenaline in pharmaceutical and clinical samples; A nanostructure electroanalytical strategy JO - Eurasian Chemical Communications JA - ECC LA - en SN - 2717-0535 AU - Moshirian-Farahi, Sareh Sadat AU - Zamani, Hassan Ali AU - Abedi, Mohamadreza AD - Department of Applied Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran AD - Department of Applied Chemistry, Quchan Branch, Islamic Azad University, Quchan, Iran Y1 - 2020 PY - 2020 VL - 2 IS - 6 SP - 702 EP - 711 KW - Isoprenaline KW - NiO-based composite KW - Nanostructure sensor KW - Modified carbon paste electrode KW - Drug sensor DO - 10.33945/SAMI/ECC.2020.6.7 N2 - A high sensitive electroanalytical-based sensor for determination of isoprenaline was fabricated by modification of carbon paste electrode (CPE) by NiO-Pt-Pd/CNTs composite as conductive mediator and n-hexyl-3-methylimidazolium hexafluoro phosphate (NHIHP) as conductive binder. The NHIHP/NiO-Pt-Pd/CNTs/CPE was improved the oxidation signal of isoprenaline ⁓3.47 times and reduced oxidation over-potential of drug ⁓180 mV. The pH investigation confirmed that redox behavior of isoprenaline is depended of pH solution with equal value of electron and proton in redox mechanism. The NHIHP/NiO-Pt-Pd/CNTs/CPE was successfully used for determination of isoprenaline in the concertation range 0.003-300 µM with detection limit 0.9 nM by square wave voltammetric method. The standard addition results showed powerful ability of NHIHP/NiO-Pt-Pd/CNTs/CPE as an electroanalytical tool for determination of isoprenaline in the pharmaceutical and clinical samples with recovery data 98.76-105.06%. UR - https://www.echemcom.com/article_105259.html L1 - https://www.echemcom.com/article_105259_d0d00afd36160ca3eb803f6c83942244.pdf ER -