TY - JOUR ID - 148643 TI - Estimation and development of some biophysical characteristics of the drug Favipiravir used in the treatment of corona-virus using green chemistry technology JO - Eurasian Chemical Communications JA - ECC LA - en SN - 2717-0535 AU - Alwan, Liqaa Hussein AU - Al Samarrai, Eman Thiab AU - Mahmood, Mahmood S.H. AU - Ali, Qaaed Baker AU - Al Samarrai, Othman Rashid AD - Department of Chemistry, College of Education, Samarra University, Samarra, Iraq AD - Department of Research and Development in the State Company for Drugs Industry and Medical Appliance, Samarra, Iraq Y1 - 2022 PY - 2022 VL - 4 IS - 9 SP - 835 EP - 851 KW - corona virus KW - Favipiravir KW - Adsorption KW - CuNPs KW - Green chemistry DO - 10.22034/ecc.2022.332743.1352 N2 - This study included the preparation and identification of copper oxide nanoparticles (CuNPs) prepared from eucalyptus leaf extract using modern and advanced detection and analysis devices: XRD, AFM, SEM, UV-Vis, and TEM. The results of the tests indicated that the prepared particles are spherical and rod-shaped, with average diameters ranging from 32.55-37.94 nm, and the results showed that the copper oxide nanoparticles were within the nano-scale, and the wavelength of the drug is (322) nanometers. The factors affecting the loading of the drug (Favipiravir) at a concentration of (40 µg/mL) on the surface of activated charcoal prepared from eucalyptus leaves were studied, as well with a weight of 0.1 g and in the presence of copper oxide nanoparticles with different concentrations. It was found that the equilibrium time is 25 minutes, and the thermodynamic functions were calculated at different temperatures. The results illustrated that the loading process by using exothermic adsorption (physical adsorption), is less random process and spontaneously. The possibility of using the loaded substance (Favipiravir:CuNPs) to inhibit microorganisms such as viruses, bacteria, and fungi was studied, and by the presence of the surface active substance sodium dodecyl sulphate SDS, it was found that it has the ability to inhibit by 100%, as a result of the merging of the tail of the superficial active substances with the fatty membrane of the virus, the other microorganisms, its dismantling, and encapsulation of its parts. The vaccines and therapeutic drugs developed on the basis of nano-medicine, which are currently undergoing clinical trials, have the potential to become innovative alternatives to defeat COVID-19 in the future. UR - https://www.echemcom.com/article_148643.html L1 - https://www.echemcom.com/article_148643_e10a10e475d5e18eea025bb21b62294e.pdf ER -