The fruit of Cordia myxa (C. myxa) is widely used for the treatment of respiratory and urinary infections, and as a diuretic, astringent, demulcent and expectorant agent. Other pharmacological effects such as anti-inflammatory, antibacterial, antiviral, anti-allergic, antitumor and antioxidants activity have also been reported for C. myxa by other studies. This study aimed to compare different extraction methods and offer a way to produce an easy-to-use formulation. In this study, extracts from the fresh and dried fruits of C. myxa were obtained using four extraction methods including soxhlet, maceration, percolation and digestion. Extraction from the dried fruits showed better results compared with that of the fresh fruits. Also, the soxhlet method of extraction using dry powdered fruits was the most efficient for extraction of active components of C. myxa fruits. Preliminary phytochemical screening showed the aqueous extract of fruits to be full of active ingredients such as alkaloids, flavonoids, tannins, phenolic compounds, Steroids, carbohydrates, and saponins. Finally, an oral syrup formulation from C. myxa fruits extract was prepared for the first time and its physicochemical properties such as light transmittance, visual inspection, pH measurement, sucrose concentration, viscosity, and antimicrobial tests were evaluated. The applied method is a quite easy, simple, environmental friendly and convenient way for extraction and oral syrup preparation of C. myxa fruits.