Web of Science (Emerging Sources Citation Index), ISC

Document Type : Original Research Article


1 Department of Pharmaceutical Technology and Management, Azerbaijan Medical University, Baku, Azerbaijan

2 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

3 Department of Biophysics and Biochemistry, Baku State University, Baku, Azerbaijan

4 Russian Institute for Advanced Study, Moscow State Pedagogical University, 1/1, Malaya Pirogovskaya St, Moscow, Russian Federation, 119991

5 Maragheh UnMaragheh University of Medical Sciences, Maragheh, Iraniversity of Medical Sciences


This study focuses on obtaining an extract from clove and calendula plants with colloidal nanoparticles of silver in the presence of 40% propyleneglycol and preparation of hydrophilic gel based on the resulting extract. Also, the optimal composition of the gel and releasing of biologically active substances from gels based on chitosan, sodium carboxymethylcellulose, carbopol, used as gelling agents was evaluated. The results showed that the release of bioactive compounds from a chitosan-based gel is more complete and intensive. The antibacterial and antifungal properties of chitosan gel containing silver nanoparticles have been confirmed by microbiological studies.

Graphical Abstract

Development of novel antibacterial gel using clove and calendula extracts with colloidal silver nanoparticles


Main Subjects

[1] M.N. Veliyeva, S.J. Mehraliyeva, S.E. Musayeva, E.A. Quliyeva, P.M. Veliyev, Sciences of Europe, 2019, 1, 3-8.
[2] ГОСТ 31695-2012 Cosmetic gels. General specifications.
[3]  Мехралиева С.Д. // Медицинский журнал Грузии, Тбилиси, 2008, 4, 31-35.
[4]  М.В. Самсонова // Пульмонология,  2008,  5, 5–13.
[5] В.А. Александрова, Л.Н. Широкова. Патент РФ № 2474471. / Опубл. 10.02.2013; бюлл. № 4.
[6] S. Qixiang, Patent CN № 104415090, Publ. 18.03.2015.
[7] L. Wei, X. Chanchan. Patent CN № 103785857. / – Publ. 14.05.2014.
[8] L. Jinjun, S. Weiyi, L. Qiangbay Patent CN № 103933067. – Publ. 23.07.2014.
[9] World Health Organization, WHO monographs on selected medicinal plants, WHO, Geneva, 2004, 2, 67–82.
[10] K. Baskaran, Int. J. Sci. Res., 2017, 6, 43-47.
[11] K.M. Alsaraf, I.S. Abbas, E.F. Hassan, In IOP Conference Series: Materials Science and Engineering, 2019, 571, 012082.
[12] M. Kim, Y. Ahn, K. Lee, W. Jung, C. Cha, Carbohydr. Polym., 2020, 229, 115538.
[13] E.J. Lee, E. Kang, S.W. Kang, K.M. Huh, Carbohydr. Polym., 2020, 244, 116432.
[14] P.L. Taylor, O. Omotoso, J.B. Wiskel, D. Mitlin, R.E. Burrell, Biomaterials, 2005, 26, 7230-7240.
[15] J.B. Wright, K. Lam, A.G. Buret, M.E. Olson, R.E. Burrell, Wound Repair Regen, 2002, 10, 141-51.
[16] K. Dumycz, K. Katarzyna, F. Wojciech, Clin. Transl. Allergy, 2019, 9, 1-5.
[17] L. Ran, Y. Zou, J. Cheng, F. Lu, Int. J. Biol. Macromol., 2019, 125, 392-403.
[18] I.C. Carvalho, H.S. Mansur, Mater. Sci. Eng. C, 2017, 78, 690-705.
[19] A. Oryan, S. Sahvieh, Int. J. Biol. Macromol., 2017, 104, 1003-1011.
[20] H. Karimi-Maleh, B.G. Kumar, S. Rajendran, J. Qin, S. Vadivel, D. Durgalakshmi, F. Gracia, M. Soto-Moscoso, Y. Orooji, F. Karimi, J. Mol. Liq., 2020,314, 113588.
[21] H. Karimi-Maleh, F. Karimi, Y. Orooji, G. Mansouri, A. Razmjou, A. Aygun, F. Sen, Sci. Rep., 2020, 10, 1-13.
[22] H. Karimi-Maleh, Y. Orooji, A. Ayati, S. Qanbari, B. Tanhaei, F. Karimi, M. Alizadeh, J. Rouhi, L. Fu, M. Sillanpää, J. Mol. Liq., 2020, 329, 115062.