Anti-cancer and antioxidant activities of some new synthesized 3-secondary amine derivatives bearing imidazo [1,2-A] pyrimidine

Rehan, Thamer A.; Al-Lami, Naeemah; Alanee, Rafal Shakeeb

doi:10.22034/ecc.2021.277531.1151

Document Type : Review Article

Authors

¹ aDepartment of Chemistry, College of Sciences, University of Baghdad, Iraq

² Department of Chemistry, Collage of Sciences, University of Baghdad, Iraq

³ College of Pharmacy, Al-Nahrain University, Iraq

https://doi.org/10.22034/ecc.2021.277531.1151

Abstract

In this study, new series of 2-aryl-3-(pyrimidine-2-ylamino)imidazo[1,2-a]pyrimidine derivatives (3-secondary amine) were synthesized through one-pot reaction of aromatic ketones and 2-aminopyrimidine. These reactions were performed in the presence of I₂and DMSO. Derivatives of 3-amine compound were reacted with propargyl bromid to yield 2-phenyl-N-(prop-2-yn-1-yl)-N-(pyrimidine-2-yl) derivatives of imidazo/pyrimidine rings. Then, by Mannich reaction, one of 3-secondary amine derivatives (contains NH2 group) (1d) was reacted with different aromatic amines to form Mannich bases. All synthesized compounds were characterized via FT-IR spectroscopy, some of which were characterized by ¹H-NMR spectroscopy. Other derivatives of imidazo(1,2-a)pyrimidine(1c,2c,2d,3a) were evaluated for anti-oxidant activity and one of these derivatives (2d) was tested for cytotoxic activity against breast cancer using MTT assay.

Graphical Abstract

Keywords

Main Subjects

Applied Chemistry

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Eurasian Chemical Communications

Anti-cancer and antioxidant activities of some new synthesized 3-secondary amine derivatives bearing imidazo [1,2-A] pyrimidine

References

References

Volume 3, Issue 5
May 2021
Pages 339-351

Anti-cancer and antioxidant activities of some new synthesized 3-secondary amine derivatives bearing imidazo [1,2-A] pyrimidine

References

References

Volume 3, Issue 5May 2021Pages 339-351

Volume 3, Issue 5
May 2021
Pages 339-351