Web of Science (Emerging Sources Citation Index), ISC

Document Type : Original Research Article

Authors

1 Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq

2 Department of chemistry, College of Sciences, University of Baghdad, Baghdad, Iraq

Abstract

In this research, cyclic compounds derived from 2- furfural mercaptan (oxazole, triazoles) were synthesized, and their biological efficacy was measured and compared with standard drugs. Also, their effectiveness as anti-oxidant was measured and compared with ascorbic acid as a standard substance. Some of the synthesized compounds were deduced with good efficacy.

Graphical Abstract

Synthesis of new heterocyclic derivatives from 2-furyl methanethiol and study their applications

Keywords

Introduction

Triazoles are the class of heterocyclic compounds which are under study since many years. The five membered triazole ring exists in two isomeric forms i.e., 1, 2, 3-triazole and 1, 2, 4-triazole[1] (Figure 1).

[1] R. Singh, A. Chouhan, World J. Pharm. Pharm. Sci., 2014, 3, 874-906. [Pdf], [Google Scholar], [Publisher]
[2] A.A. Othman, M. Kihel, S. Amara,             Arab. J. Chem., 2019, 12, 1660-1675. [crossref], [Google Scholar], [Publisher]
[3] H.M. Dalloul, Can. Chem. Trans., 2015, 3, 108-117. [crossref], [Google Scholar], [Publisher]
[4] X. Li, X.Q. Li, H.M. Liu, X.Z. Zhou, Z.H. Shao, Org. Med. Chem. Lett., 2012, 2, 1-5. [Pdf], [Google Scholar], [Publisher]
[5] M.R. Aouad, M.A. Soliman, M.O. Alharbi, S.K. Bardaweel, P.K. Sahu, A.A. Ali, M. Messali, N. Rezki, Y.A. Al-Soud, Molecules, 2018, 23, 2788. [crossref], [Google Scholar], [Publisher]
[6] P. Mani, P. Mahesh, C. Praveen, Y. Murthy, Der Pharma Chemica, 2015, 7, 116-120. [Pdf], [Google Scholar], [Publisher]
[7] N. Singhal, P. Sharma, R. Dudhe, N. Kumar, J. Chem. Pharm. Res., 2011, 3, 126-133. [Pdf], [Google Scholar], [Publisher]
[8] H.M. Sadiq, World J. Pharm. Pharm. Sci., 2017, 6, 186-198. [crossref], [Google Scholar], [Publisher]
[9] N.M. Aljamali, Experimental Methods for Preparation of ((Mannich Bases, Formazan, Normal and Cyclic Sulfur Compounds)),Evince pub Publishing House, 2018, 1-20. [Pdf], [Google Scholar], [Publisher]
[10] J. Slouka, P. Peč, J. Urbanová, Acta Universitatis Palackianae Olomucensis. Facultas Rerum Naturalium. Mathematica-Physica-Chemica, 1972, 12, 481-483. [Pdf], [Google Scholar], [Publisher]
[11] H. Sangani, K. Bhimani, R. Khunt, A. Parikh, J. Serb. Chem. Soc., 2006, 71, 587-591. [crossref], [Google Scholar], [Publisher]
[12] I.K. Jassim, Kerbala Journal of Pharmaceutical Sciences, 2011, 2, 196-217. [Pdf], [Google Scholar], [Publisher]
[13] A.H. El-masry, H. Fahmy, S. Ali Abdelwahed, Molecules, 2000, 5, 1429-1438. [crossref], [Google Scholar], [Publisher]
[14] F. AYDOĞAN, Z. Turgut, N. Öcal, S.S. ERDEM, Turk. J. Chem., 2002, 26, 159-170. [Pdf], [Google Scholar], [Publisher]
[15] S.A.A. Jabbar, Karbala Journal of Pharmaceutical Sciences, 2018, 9, 50-64. [Pdf], [Google Scholar], [Publisher]
[16] A.S. Grewal, S. Redhu, Int. J. Pharmtech. Res., 2014, 6, 2015-2021. [Pdf], [Google Scholar], [Publisher]
[17] L.S. Ahamed, J. Glob. Pharma. Technol., 2009, 10, 298-304. [Pdf], [Google Scholar], [Publisher]
[18] M.R. Ahamad, T.S. Hussain, Int. J. Sci. Res., 2017, 6, 1060-1066.  [crossref], [Google Scholar], [Publisher]
[19] N.A. Aksenov, N.A. Arutiunov, N.K. Kirillov, D.A. Aksenov, A.V. Aksenov, M. Rubin, Chem. Heterocycl. Comp., 2020, 56, 1067-1072. [crossref], [Google Scholar], [Publisher]
[21] M. Olszowy, A.L. Dawidowicz, Chemical Papers, 2018, 72, 393-400. [crossref], [Google Scholar], [Publisher]
[22] N. Jadid, D. Hidayati, S.R. Hartanti, B.A. Arraniry, R.Y. Rachman, W. Wikanta, AIP Conference Proceedings, 2017, 1854, 020019. [crossref], [Google Scholar], [Publisher]