High-intensity exercise produces free radicals in the body, resulting in oxidative stress. The presence of oxidative stress can be determined by measuring superoxide dismutase and malondialdehyde levels. Consuming foods in a high range in antioxidants is one way to prevent oxidative stress in the body. Purple Sweet Potato (Ipomoea batatas var. Antin 3) has anthocyanins and vitamin C, which can fight free radicals and keep the body healthy. To find out how Ipomoea batatas var. Antin 3 can help prevent oxidative stress after a lot of exercise in rat. The experimental research with a post-test only control group design. The number of rats is 24, then they were divided into four groups. Group I was given the standard feed, while Group II was given both exercise and the standard feed. Group III was given exercise, standard feed, and purple sweet potato 2.6 mg/day. Group IV was given exercise, standard feed, and purple sweet potato 5.2 mg/day. The physical exercise was given every day for 28 days. Observation of SOD and MDA levels was done by spectrophotometry. Analysis using one-way ANOVA and post hoc LSD revealed that administration of purple sweet potato at a dose of 5.2 mg/day was the most effective dose for decreasing MDA levels (p<0.05) and increasing SOD activity (p<0.05), as well. Giving purple sweet potatoes prevented the accumulation of oxidative stress, but administration of purple sweet potatoes at a dose of 5.2 mg/day was more effective in preventing the buildup of free radicals which cause oxidative stress in the body.