Document Type : Original Research Article

Authors

1 Department of medical chemistry ,College of pharmasy ,Baghdad university

2 Department of Pharmaceutical Chemistry, College of Pharmacy, Mosul University

3 Department of Pharmaceutics, College of Pharmacy, University of Baghdad

Abstract

By the Biginelli reaction of substituted aromatic aldehydes, cyano- ethyl acetate, and urea/ thiourea in absolute ethanol the 1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile derivatives were synthesized (compounds 1a-d). In the next step Acid compounds (2a-d) were formed via the hydrolysis of nitrile group using sulfuric acid (70%), and condensed with the appropriated amino phenol to give the corresponding N-Aryl-1, 2, 3, 4-tetrahydropyrimidine-5-carboxamide derivatives (3a-d). FTIR, 1H-NMR, and 13C-NMR were used to verify the structures of the discovered compounds. All of these novel compounds yielded spectroscopic evidence consistent with their suggested structures. Compounds with significant antibacterial action against Candida neoformans (ATCC 208881, H99 Type strain) and Candida albicans (ATCC 90028, CLSI reference) were found in Australia

Graphical Abstract

Synthesis, in silico ADMET, docking, antioxidant and antimicrobial evaluations of some pyrimidine derivatives

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Main Subjects