Document Type : Original Research Article

Authors

1 Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2 Marine Pharmaceutical Science Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

3 Department of Medicinal Chemistry, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Abstract

In the present work, Se and Mn analysis was carried out among some popular Iranian herbal drops to monitor a possible accumulation of adverse elements. In this study, five different herbal drops present in Iranian market were selected, and 45 samples of each (totally 225 samples) were collected, and analyzed for the presence and determination of selenium and manganese using graphite furnace atomic absorption spectrometry. Samples were prepared by the dry ashing method at 450 °C, and the residue was dissolved in nitric acid. Se and Mn contents were determined using calibration curves at wavelength 196.0 and 279.5 nm respectively. LOD of the methods were determined as 9.1 µgL-1 for Se and 0.9 µgL-1 for Mn. LOQs were calculated to be 30.0 and 3.0 µgL-1 for Se and Mn, respectively. The Se concentrations in the determined samples were between ND-21.0 µgL-1 and for Mn were in the range of 7.2-1840.7 µgL-1. Mean Se and Mn concentrations (µgL-1) were 4.7 and 43.7 for Vitagnus, 9.6 and 185.1 for Hypiran, 13.3 and 338.5 for Carminat, 21.0 and 1840.7 for Persica, and ND and 7.2 for Menthol, respectively. The results showed that Mn was present in all of the samples analyzed, but no selenium was detected in some herbal drop samples.

Graphical Abstract

Determination of manganese and selenium levels in Iranian herbal drops by graphite furnace atomic absorption spectrometry technique

Keywords

Main Subjects

[1] J.G. Graham, M.L. Quinn, D.S. Fabricant, N.R. Farnsworth, Plants used against cancer – an extension of the work of Jonathan ‎Hartwell, J. Ethnopharmacol., 2000, 73, 347-377. [Crossref], [Google Scholar], [Publisher]
[2] N.F. Kolachi, T.G. Kazi, H.I. Afridi, S. Khan, S.K. Wadhwa, A.Q. Shah, F. Shah, J.A. Baig, Sirajuddin, Determination of selenium content in aqueous extract of medicinal ‎plants used as herbal supplement for cancer patients, Food Chem. Toxicol., 2010, 48, 3327-3332. ‎[Crossref], [Google Scholar], [Publisher]
[3] S. Ražić, A. Onjia, B. Potkonjak, Trace elements analysis of Echinacea purpurea—‎herbal medicinal, J. pharm. Biomed. Anal., 2003, 33, 845-‎‎850. [Crossref], [Google Scholar], [Publisher]‎
[4] L. Shun‐xing, Z. Feng-ying, L. Xian-li, C. Wen-lian., Speciation analysis and the assessment of bioavailability of manganese ‎in phytomedicines by extraction with octanol and determination by flame atomic absorption ‎spectrometry, Phytochem. Anal., 2005, 16, 405-410. ‎[Crossref], [Google Scholar], [Publisher]
[5] W.N.N. Mezaal, S.A. ALsahib, Synthesis and characterization of new derivatives using ‎Schiff’s bases for alcoholic extract of (Cordia myxa) medical plant, Eurasian Chem. Commun., 2022, 4, 1054-1061. ‎[Crossref], [Google Scholar], [Publisher]
[6] (a) H.T. Salih, A.H. Hamed, Extraction and determination of tannic acid in rosemary, ‎anise, and cinnamon by reversal phase RP-HPLC, Eurasian Chem. Commun., 2022, 4, 94-‎‎102. ‎[Crossref], [Google Scholar], [Publisher], (b) V. Safari Fard, Y. Davoudabadi Farahani, An amine/imine functionalized microporous MOF as a new fluorescent probe exhibiting selective sensing of Fe3+ and Al3+ over mixed metal ions, J. Appl. Organomet. Chem., 2022, 2, 180-194. ‎[Crossref], [Google Scholar], [Publisher]
[7] M. Shahmohammadi, M. Bahmani, H. Ghaneialvar, N. Abbasi, Extraction and identification of the components of Thymbra ‎spicata L. and Satureja khuzestanica Jamzad Oils native to Ilam province by headspace-‎solid phase microextraction (HS-SPME) and gas chromatography-mass spectrometry (GC-‎MS), Eurasian Chem. Commun., 2021, 3, 841-853. ‎[Crossref], [Google Scholar], [Publisher]
[8] (a) M. Ravanbakhsh, S. Mahernia, K. Bagherzadeh, O.G. Dadrass, M. Amanlou, Determination of heavy metals (Cd, Pb, Cu) in some herbal drops ‎by Polarography, Iran. J. Pharmacol. Ther., 2017, 1, 4. ‎[Pdf], [Google Scholar], [Publisher], (b) F. Ismail Ahmadi, R. Fathollahi, D. Dastan, Phytochemical constituents and biological properties of Scutellaria condensata subsp. Pycnotricha, J. Appl. Organomet. Chem., 2022, 2,  119-128. ‎[Crossref], [Google Scholar], [Publisher]
[9] O. Barchuk, R.M. Lysiuk, A.I. Denys, O.M. Zaliska, O.G. Smalyuh, M.I. Nester, Experimental study of goat’s rue (Galega Officinalis L.) herb and its ‎liquid extracts, Pharma Innovation, 2017, 6, 393-397. [Google Scholar], [Publisher]
[10] C. Luka, G. Adoga, G. Istifanus, Phytochemical studies of different fractions of ‎Galega officinalis extract and their effects on some biochemical parameters in alloxan-‎induced diabetic rats, 2017. [Crossref], [Google Scholar], [Publisher]‎
[11]  D.R. Lide, Magnetic susceptibility of the elements and inorganic compounds, CRC handb. chem. phys., 2005, 81, 130-135. ‎[Crossref], [Google Scholar]
[12] K. Schwarz,C.M. Foltz, Selenium as an integral part of factor 3 against dietary necrotic ‎liver degeneration, J. Am. Chem. Soc., 1957, 79, 3292-3293. ‎‎[Crossref], [Google Scholar], [Publisher]
[13] R.F. Clark, E. Strukle, S.R. Williams, A.S. Manoguerra, PharmD, Selenium poisoning from a nutritional supplement, J. Am. Med. Assoc., 1996, 275, 1087-1088. ‎[Crossref], [Google Scholar], [Publisher]
[14] H.J. Sun, B. Rathinasabapathi, B. Wu, J. Luo, L.P. Pu, L. Q. Ma, Arsenic and selenium toxicity and their interactive effects in humans, ‎Environ. Int., 2014, 69, 148-158. ‎[Crossref], [Google Scholar], [Publisher]
[15] A.N. Jasima, Z.G. Hussien, H. Fares Abd-Alrazac, M.A. Majid, Estimation of the total amounts of manganese ions in some of the ‎medicinal plants leaves using flow injection technique combined with photometric detection ‎method, Eurasian Chem. Commun., 2022, 4, 7-15. ‎[Crossref], [Google Scholar], [Publisher]
[16]  J.M. Schaefer, T. Faestermann, G.F. Herzog, K. Knie, G. Korschinek, J. Masarik, A. Meier, M. Poutivtsev, G. Rugel, C. Schlüchter, F. Serifiddin, G. Winckler, Terrestrial manganese-53—a new monitor of Earth surface processes, ‎ Earth Planet. Sci. Lett., 2006, 251, 334-345. ‎[Crossref], [Google Scholar], [Publisher]
[17] D. Ekinci, M. Senturk, Assesment of metal inhibition of antioxidant enzyme glutathione ‎reductase from rainbow trout liver, J. Enzyme Inhib. Med. Chem., 2013, 28, 11-15. ‎ [Crossref], [Google Scholar], [Publisher]‎
[18] M. Wieser, Atomic weights of the elements 2005 (IUPAC Technical Report), Pure Appl. Chem., 2006, 78, 2051-2066. [Crossref], [Google Scholar], [Publisher] ‎‎
[19] P. Olmedo, A.F. Hernández, A. Pla, P. Femia, A. Navas-Acien, F. Gil, Determination of essential elements (copper, manganese, selenium and ‎zinc) in fish and shellfish samples. Risk and nutritional assessment and mercury–selenium ‎balance, Food Chem. Toxicol., 2013, 62, 299-307. [Crossref], [Google Scholar], [Publisher] ‎
[20] E. Salmerón-Manzano, J.A. Garrido-Cardenas, F. Manzano-Agugliaro, Worldwide ‎research trends on medicinal plants, Int. J. Environ. Res. Public Health, 2020, 17, 3376. ‎[Crossref], [Google Scholar], [Publisher]