Web of Science (Emerging Sources Citation Index)

Document Type: Original Research Article

Authors

1 Department of Chemistry, Khouzestan Science and Research Branch, Islamic Azad University, Ahvaz, Iran

2 Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran

3 Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

4 Department of chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran

10.33945/SAMI/ECC.2019.5.5

Abstract

In this paper we present the convenient syntheses of seven new phenyl hydrazin derivatives 8 (a-h). For this purpose, acenaphtho [1,2-e]-1,2,4-triazine-9(8H)-thione (3) was prepared, starting from acenaphthylene-1, 2-dione (1) and thiosemicabazide in good yield. The reaction of (3) with benzyl chloride resulted to synthesis of 9-(benzylthio)-acenaphtho[1,2-e]-1,2,4-triazines (5) that reacted with hydrazine to synthesis of 9-(hydrazino)-acenaphtho [1, 2-e]-1, 2, 4-triazines (6). This compound reacted with different aromatic aldehyde derivatives (7 a-h) that resulted to synthesis of final product, 9-(phenyl imino hydrazine)-acenaphtho [1, 2-e]-1, 2, 4-triazine derivatives (8 a-h) in good yield. The cytotoxicity of the synthesized compounds were also studied against human cancer cell lines including breast (MCF-7), ovarian (SKOV3) and lung (A549) cell lines.
 
 

Graphical Abstract

Keywords

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