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Document Type: Original Research Article


1 Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran

2 Research Center for Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran

3 Esfarayen University of Technology, Esfarayen, Iran

4 eDepartment of Chemistry, Faculty of Science, Qom University, Qom, Iran



Electrochemical behaviors of epinephrine and acetylcholine were investigated using cyclic voltammetry, on the Ag-ZnO modified screen-printed electrode (Ag-ZnO/SPE). Ag-ZnO nanoplates showed excellent electrocatalytic activity toward the oxidation of epinephrine and acetylcholine compared with bare SPE in 0.1 M PBS. Under the optimized experimental conditions, a linear response obtained in the range of 0.13 to 450.00 μM with detection limit of 0.04 μM for epinephrine. Ag-ZnO/SPE exhibits good stability, reproducibility and repeatability, and the method has been successfully applied for detection of epinephrine and acetylcholine in their pharmaceutical and biological samples with satisfactory recovery.

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