@article { author = {Mhaibes, Raed and Al-Tamimi, Entesar}, title = {Synthesis of new heterocyclic containing azo group from 2-N-chloro acetamido creatinine and studying their biological activity}, journal = {Eurasian Chemical Communications}, volume = {3}, number = {6}, pages = {401-405}, year = {2021}, publisher = {Sami Publishing Company (SPC)}, issn = {2717-0535}, eissn = {2676-6280}, doi = {10.22034/ecc.2021.281946.1170}, abstract = {The present work include synthesized new 2-amino-4-subs. thiozole(1) from reaction of 2-N-chloro acetamido Creatinine with thiourea. Compound (1) was treated with sodium nitrate and hydrochloric acid in (0-5ºC) to form diazonium salt (2), then   diazonium salt reacted with acetylacetone and hydrazine, phenyl hydrazine and 2,4-dinitrophenyl hydrazine to give pyrazole ring (4-6). On the other hand, diazonium salt was react with pyrrole in the presence of glacial acetic acid to form compound (7) and with different Schiff bases to produce compounds (8-9). Prepared compounds were measured by IR and melting point and some of them by 1HNMR and their biological activity was studied.                                                        }, keywords = {thiozole,Diazonium salt,azo compounds,Biological activity}, url = {https://www.echemcom.com/article_130623.html}, eprint = {https://www.echemcom.com/article_130623_6a71dad7aa732bc2ac3ba79224e2d72c.pdf} }