%0 Journal Article %T Synthesis and characterization of some new heterocyclic compounds (hydroqinazoline and thiazinone) prepared from Schiff bases derived from flucytosine drug and study of biological activity %J Eurasian Chemical Communications %I Sami Publishing Company (SPC) %Z 2717-0535 %A Majeed, Nadia Sadiq %A Hussein, Rasha Neama %D 2023 %\ 07/01/2023 %V 5 %N 7 %P 642-660 %! Synthesis and characterization of some new heterocyclic compounds (hydroqinazoline and thiazinone) prepared from Schiff bases derived from flucytosine drug and study of biological activity %K Flucytosine %K Schiff bases %K Hydroqinazoline %K Thiazinone %K Biological activity %R 10.22034/ecc.2023.389454.1606 %X A series of some new heterocyclic six–membered compounds has been synthesized from Flucytosine drug, containing a terminal primary amine group, and was used to prepare a number of new Schiff base compounds bearing the numbers (A1-A4) through interaction with different aldehydes and ketones and using ethanol absolute as a solvent. After that, it was possible to prepare several organic compounds using Schiff bases (A1-A4) prepared in the first step, which contain azomethine group react with (2-aminobenzoic acid and 2-mercaptobenzoic acid) to prepare hydroqinazoline (A5-A8) and thiazinone derivatives (A9-A12). These reactions are followed by TLC and the measurement of melting points for the derivatives. These compounds were determined by FT-IR and by 1H-NMR and 13C-NMR spectra, along with studying the biological activity of the prepared derivatives. %U https://www.echemcom.com/article_169555_97c01758787f440559cea83fdab2e5fa.pdf