TY - JOUR ID - 109382 TI - Simultaneous determination of rosuvastatin and amlodipine in binary mixtures by differential pulse voltammetry and HPLC methods JO - Eurasian Chemical Communications JA - ECC LA - en SN - 2717-0535 AU - Yilmaz, Bilal AU - Yilmaz, Nurullah AD - Department of Analytical Chemistry, Faculty of Pharmacy, Ataturk University, 25240, Erzurum, Turkey Y1 - 2020 PY - 2020 VL - 2 IS - 8 SP - 881 EP - 894 KW - Rosuvastatin KW - Amlodipine KW - Differential pulse voltammetry KW - HPLC KW - Validation DO - 10.22034/ecc.2020.109382 N2 - This research study discusses two rapid, sensitive and specific methods for simultaneous determination of rosuvastatin (ROS) and amlodipine (AML) in pharmaceutical preparations using the differential pulse voltammetry (DPV) and high-performance liquid chromatography (HPLC). Electrochemical behavior and simultaneous voltammetric determination of ROS and AML were investigated using the platinum disk electrode. HPLC was also developed for the comparison. The flow rate of the mobile phase was 1.0 mL/min and all the detections were carried out at 225 nm using the UV detection. The calibration curve was established over the concentration range of 0.5-4 mg/mLfor DPV and 0.1-2 mg/mLfor HPLC. The intra- and inter-day relative standard deviation was less than 2.96 and 3.07% for DPV and HPLC, respectively. Limits of quantification were determined as 0.21 and 0.06 mg/mLfor DPV and HPLC, respectively. Both the drugs along with their degradation products were separated in less than 8 min. No interference was found from tablet excipients at the selected assay conditions. The methods were applied for the quality control of the commercial ROS and AML drug. UR - https://www.echemcom.com/article_109382.html L1 - https://www.echemcom.com/article_109382_c7fc8edbb5fd48b2226a0612c82a8003.pdf ER -