TY - JOUR ID - 130112 TI - Anti-cancer and antioxidant activities of some new synthesized 3-secondary amine derivatives bearing imidazo [1,2-A] pyrimidine JO - Eurasian Chemical Communications JA - ECC LA - en SN - 2717-0535 AU - Rehan, Thamer A. AU - Al-Lami, Naeemah AU - Alanee, Rafal Shakeeb AD - aDepartment of Chemistry, College of Sciences, University of Baghdad, Iraq AD - Department of Chemistry, Collage of Sciences, University of Baghdad, Iraq AD - College of Pharmacy, Al-Nahrain University, Iraq Y1 - 2021 PY - 2021 VL - 3 IS - 5 SP - 339 EP - 351 KW - Imidazo[1,2-a]pyrimidine KW - One-pot reaction KW - Anti-oxidant KW - MTT assay DO - 10.22034/ecc.2021.277531.1151 N2 - In this study, new series of 2-aryl-3-(pyrimidine-2-ylamino)imidazo[1,2-a]pyrimidine derivatives (3-secondary amine) were synthesized through one-pot reaction of aromatic ketones and 2-aminopyrimidine. These reactions were performed in the presence of I2 and DMSO. Derivatives of 3-amine compound were reacted with propargyl bromid to yield 2-phenyl-N-(prop-2-yn-1-yl)-N-(pyrimidine-2-yl) derivatives of imidazo/pyrimidine rings. Then, by Mannich reaction, one of 3-secondary amine derivatives (contains NH2 group) (1d) was reacted with different aromatic amines to form Mannich bases. All synthesized compounds were characterized via FT-IR spectroscopy, some of which were characterized by 1H-NMR spectroscopy. Other derivatives of imidazo(1,2-a)pyrimidine(1c,2c,2d,3a) were evaluated for anti-oxidant activity and one of these derivatives (2d) was tested for cytotoxic activity against breast cancer using MTT assay. UR - https://www.echemcom.com/article_130112.html L1 - https://www.echemcom.com/article_130112_adc2bd58170156317cfea374bebbb7ea.pdf ER -