TY - JOUR ID - 132688 TI - Thermodynamic study and spectrophotometric determination of cefixime trihydrate in pure form and pharmaceutical tablets using batch and normal flow injection analysis JO - Eurasian Chemical Communications JA - ECC LA - en SN - 2717-0535 AU - Al-warda, Hind Sadiq AU - Ahmed, Mohammed Rifaat AU - Al-Abachi, Mouayed Qassim AD - Chemistry Department, College of Sciences, Baghdad University, Baghdad, Iraq AD - Ashur University college, Emeritus professor at College of Women Sciences, Baghdad University, Baghdad, Iraq Y1 - 2021 PY - 2021 VL - 3 IS - 7 SP - 495 EP - 507 KW - cefixime trihydrate KW - thiamine hydrochloride KW - Thermodynamic KW - flow injection KW - Spectrophotometry DO - 10.22034/ecc.2021.289383.1183 N2 - This study aimed at developing pectrophotometric methods for the determination of Cefixime Trihydrate [CFT] by simple, sensitive batch and flow-injection analysis in its purest form and tablet formulations. These developed methods were based on an oxidative coupling reaction of CFT with thaimine hydrochloride in the presence of a basic medium and using potassium ferricyanuide as an oxidant to produce a stable water-soluble, intense orange dye with a maximum absorption at 440 nm. Beer's law was followed over the concentration range [2.5-75 and 10-400 µg.mL-1] of CFT with limits of detection of 0.7223 and 2.6145 µg.mL-1 of CFT for batch and FIA methods, respectively. The average sample throughput for the FIA was 68 h-1. The effects of various chemical and physical experimental parameters on the development and stability of the colored product were carefully investigated. CFT estimated in commercial tablets forms was successfully applied using these methods, in which the results were in good agreement with those produced using the official procedure. Thermodynamic parameters, including the free energy changes [∆G], enthalpy [∆H] and entropy [∆S] were determined at different temperatures for the reaction product. UR - https://www.echemcom.com/article_132688.html L1 - https://www.echemcom.com/article_132688_40eef247bb241e4d0cb2c0a124e652f1.pdf ER -