TY - JOUR ID - 143425 TI - Modification and characterization of subs. triazole on creatinine and studying their antioxidant activity JO - Eurasian Chemical Communications JA - ECC LA - en SN - 2717-0535 AU - Sallal, Zainab Amer AU - Al-Tamimi, Entesar O. AD - Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq Y1 - 2022 PY - 2022 VL - 4 IS - 2 SP - 152 EP - 159 KW - Creatinine KW - Imide KW - acid hydrazide KW - 1,2,4-Triazole KW - Antioxidant activity DO - 10.22034/ecc.2022.320360.1280 N2 - In this work, new creatinine derivatives containing (1,2,4-triazole and 5-subs-1,2,4-triazole) ring have been prepared. In the first step, creatinine was reacted with different acid chloride to form 2-subs. amido creatinine 1[a-d]. In the second step, amido creatinine 1[a-d] was reacted with succinoyl chloride to produce imide derivatives 2[a-d]. In the third step, the imide componds prepared were reacted with hydrazine hydrate to give acid hydrazide derivatives 3(a-d). Finally, 1,2,4-triazole derivatives 4-7[a-d] were prepared from the reaction between acid hydrazide with different amide compounds by pellizzari reaction. These new synthesized products have been characterized by FT-IR, 1H-NMR for some of them and were studied regarding the effect of preparing derivatives on antioxidant. UR - https://www.echemcom.com/article_143425.html L1 - https://www.echemcom.com/article_143425_5b059cb36af028515b9f705e1db07615.pdf ER -