Document Type : Original Research Article
Department of Chemistry, Payame Noor University, P.O. BOX 19395-4697 Tehran, Iran
2-Amino-4H-pyran derivatives are reported to have a broad spectrum of biological and pharmacological activities. Some are endowed with anticoagulant, spasmolitic, diuretic, anticancer and antianaphylactin. On the other hand, some 2-amino-4H-pyrans also can be employed as cognitive enhancers, for the treatment of neurodegenerative disease, including Alzheimer's disease, amyotrophic. In this research, 2-amino-4H-pyran derivatives were synthesized with good yields via a one-pot multi–component reaction of aldehyde, malononitrile, and dimedone in the presence of DABCO-CuCl as a catalyst in water.