Scopus (CiteScore 2022 =3.0, Q3) , ISC

Document Type : Original Research Article

Authors

1 Department of Chemistry, Faculty of Science, Arak University, 38156-8-8349, Arak, Iran

2 Institue of Nanosciences & Nanotechnolgy, Arak University, 38156-8-8349, Arak, Iran

10.33945/SAMI/ECC.2019.2.2

Abstract

A biocompatible microemulsion system comprising of isopropyl myristate (IPM) as oil, tween 80 as a non-ionic surfactant and isobuthanol as co-surfactant was studied experimentally at 298.15 K. The pseudo-ternary phase diagram for the microemulsion system has been delineated at different surfactant to co-surfactant mass ratio of 1:1, 2.4:1 and 4:1. Some physico-chemical properties such as density, viscosity, refractive index, conductivity and pH, for a typical surfactant to co-surfactant mass ratio of 2.4:1 were determined precisely. It is verified that the transition point of viscosity, conductivity, refractive index and density occurs at about 30 wt% of water. The transition point could be attributed to either the change in the shape of droplets or the transition from o/w microemulsion phase to bicontinuous phase.

Graphical Abstract

Physico-chemical evaluation of a biocompatible microemulsion system containing IPM/Tween80/Isobutanol

Keywords

[1] J. Eastoe, In: T. Cosgrove (editor) Colloid science: principles, methods and applications, Blackwell Publishing; 2005, P. 77.
 
[2] J. Eccleston, In: J. Swarbrick, J.C. Boylan (editors). Encyclopedia of Pharmaceutical Technology. vol. 9. New York, NY, Marcel Dekker, 1994, P. 375.
 
[3] N. Grampurohit, P. Ravikumar, R. Mallya, Ind. J. Pharm. Edu. Res., 2011, 45, 100-107.
 
[4] A. Salabat, F. Dehghani Sanij, Bull. Korean Chem. Soc., 2012, 33, 3387-3390.
 
[5] S.P. Moulik, A.K. Rakshit, J. Surface Sci. Technol., 2006, 22, 159-186.
 
[6] A. Salabat, H. Saydi, Polym. Composite, 2014, 35, 2023-2028.
 
[7] G. Shishu, A. Prabhleen, K. Neeraj, P. Ashana, AAPS PharmSciTech, 2014, 15, 810-821.
 
[8] T. Schmidts, P. Nocker, G. Lavi, J. Kuhlmann, P. Czermak, F. Runkel, Colloid Surf. A: Physicochem. Eng. Aspects, 2009, 340, 187-192.
 
[9] A. Salabat, J. Eastoe, K. J. Mutch, R. F. Tabor, J. Colloid Interf. Sci., 2008, 318, 244-251.
 
[10] R. Sripriya, K. Muthu Raja, G. Santhosh, M. Chandrasekaran, M. Noel, J. Colloid Interf. Sci., 2007, 314, 712-717.
 
[11] A. Kajbafvala, A. Salabat, A. Salimi, Pharm. Dev. Technol., in press: doi.org/10.1080/10837450.2016.1263995.
 
[12] S.K. Mehta, G. Kaur, K.K. Bhasin, Colloid Surf. B: Biointerfaces, 2007, 60, 95-104.
 
[13] S. Hickey, S.A. Hagan, E. Kudryashova, V. Buckina, Int. J. Pharm., 2010, 388, 213-222.
 
[14] X. Dong, X. Ke1, Z. Liao, Drug Dev. Ind. Pharm., 2011, 37, 894-900.
 
[15] C.A. Ayannides, G. Ktistis, J. Cosmet. Sci., 1999, 50, 1-7.
 
[16] S.K. Mehta, G. Kaur, K.K. Bhasin, Pharm. Research, 2007, 25, 227-236.
 
[17] X. Fua, F. Feng, B. Huang, Inter. J. Pharm., 2006, 321, 171-175.
 
[18] A.S. Narang, D. Delmarre, D. Gao, Inter. J. Pharm., 2007, 345, 9-25.
 
[19] M. Fanun, W.S. Al-Diyn, Colloid Surf. A: Physicochem. Eng. Aspects, 2006, 277, 83-89.
 
[20] D.P. Acharya, P.G. Hartley, Curr. Opin. Colloid Interf. Sci., 2012, 17, 274-280.
 
[21] A. Kogan, A. Aserin, N. Garti, J. Colloid Interf. Sci., 2007, 315, 637-647.