Web of Science (Emerging Sources Citation Index)

Document Type : Original Research Article

Authors

1 Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran

2 Department of Biomaterials, College of Natural Resources, North Carolina State University, United States

Abstract

In this research, a green procedure and conventional methodology have been developed for the synthesis of a series of 3-mercapto-1,2,4-triazole derivatives (4a-f) in the presence of  KF/Clinoptilolite nanoparticles (KF/CP NPs) as catalyst in water at 80 oC. Also, diphenyl-picrylhydrazine (DPPH) radical trapping and ferric reduction activity potential (FRAP) assays are used for evaluation of antioxidant activity of some synthesized compounds (4a-4d). Besides, the antimicrobial activity of some synthesized compounds was studied employing the disk diffusion test on Gram-positive bacteria and Gram-negative bacteria. This procedure has some advantages such as short time of reaction, simple and green procedure, using low-cost catalyst, excellent yield of product and employing different substrate.

Graphical Abstract

KF/CP NPs as an efficient nanocatalyst for the synthesis of 1,2,4-triazoles: Study of antioxidant and antimicrobial activity

Keywords

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