Document Type: Original Research Article

Authors

1 Research Center for Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran

2 Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran

3 Department of Chemistry, Faculty of Science, Qom University, Qom, Iran

4 Kerman University of Medical Sciences, Kerman, Iran

10.33945/SAMI/ECC.2020.1.4

Abstract

Zolpidem is an imidazopyridine derivative, non-benzodiazepine and sedative-hypnotic medicine. It is a widely prescribed medication in adults for the short-term treatment of a sleep problem called insomnia and frequent awakenings. In this paper, the zolpidem was determined directly using Ag/ZnO nanoplates modified glassy carbon electrode (Ag-ZnO/GCE). The electrochemical behavior of zolpidem was investigated by differential pulse voltammetry (DPV), chronoamperometry (CHA) and cyclic voltammetry (CV), using Ag-ZnO/GCE. The results showed that the current responses of zolpidem improved significantly because of the high catalytic activity and electron transfer reaction of nanoplates. The linear range of zolpidem was from 0.1 to 500.0 µM with the detection limit of 0.03 µM. In addition, this original sensor possesses numerous benefits such as reproducibility, high stability and rapid response (20 s).

Graphical Abstract

Keywords

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