Web of Science (Emerging Sources Citation Index), Scopus, ISC

Document Type : Original Research Article

Authors

1 Department of Biochemistry, Dentistry College, University of Tikrit, Tikrit, Iraq

2 Department of Clinical Science Laboratory, College of Pharmacy, University of Tikrit, Tikrit, Iraq

Abstract

Meningitis, an inflammation of the meninges, is globally distributed as either sporadic or epidemic forms. Acute meningitis of infectious etiology involves viruses or bacteria making the differential diagnosis very difficult. Oxidative and reductive stress are dual dynamic phases experienced by the cells undergoing adaptation towards endogenous or exogenous noxious stimulus. Considering the issue stated, the present study was designed to evaluate the alterations in different biochemical parameters including glucose, protein, oxidative stress in the CSF samples of the meningitis patients (n=36) and compare them with control subjects (n=36). The results revealed significant increase in CSF of total protein, malondialdehyde, albumin, and NO levels in meningitis patients when compared with their respective controls. While Glucose, uric acid, glutathione, Vitamin E and C were significantly decreased in CSF samples, in meningitis patients in comparison to the control group. The findings indicated that oxidative stress due to reactive nitrogen species and altered antioxidant defenses are involved in the pathophysiology of meningitis in humans.

Graphical Abstract

Study of oxidant-antioxidant status in cerebrospinal fluid of children with meningitis

Keywords

Main Subjects

[1] A.P. Hrishi, M. Sethuraman, Indian J. Crit. Care Med., 2019, 23, S115-S119. [Crossref], [Google Scholar], [Publisher]
[2] J.L. Trillo-Contreras, J.J. Toledo-Aral, M. Echevarría, J. Villadiego, Cells., 2019, 8, 197. [Crossref], [Google Scholar], [Publisher]
[3] T.A.E. Attia, A.Z. Ibrahem, L.A.E. Mohamed, A.M.A. El-Bayed, Egypt. J. Hospital Med., 2020, 80, 666-671. [Crossref], [Google Scholar], [Publisher]
[4] M.K. Sinha, S.S. Haque, R. Agrawal, J.R. Keshari, U. Kumar, A. kumar, T. Aziz, A. kumar, Curr. Trends Biomedical. Eng. Biosci., 2017, 1, 41-43. [Crossref], [Google Scholar], [Publisher]
[5] E.R. Sarhat, Z.N.M. Albarzanji, C.I. Ali Pambuk. Biomed. Pharmacol. J., 2019, 12, 2151-2155 [Crossref], [Google Scholar], [Publisher]
[6] S. Chakraborty, IOSR J. Dent. Med. Sci., 2018, 17, 26-30. [Crossref], [Google Scholar], [Publisher]
[7] M.D. Bikkad, S.D. Somwanshi, S.H. Ghuge, N.S. Nagane, Biomed. Res., 2014, 25, 84-87. [Pdf], [Google Scholar], [Publisher]
[8] E.R. Sarhat, Al-Mustansiriyah J. Sci., 2011, 22, 192-200. [Google Scholar], [Publisher]
[9] G.A. Kurian, R. Rajagopal, S. Vedantham, M. Rajesh, Oxid. Med. Cell. Longev., 2016, 2016, 14. [Crossref], [Google Scholar], [Publisher
[10] J. Madeo, C. Elsayad, J. Alzheimers Dis. Parkinsonism., 2013, 3, 116. [Crossref], [Google Scholar], [Publisher
[11] K.G. Washeel, E.R. Sarhat, T.H. Jabir, Indian J. Forensic Med. Toxicol., 2019, 13, 1500-1504. [Crossref], [Google Scholar], [Publisher] 
[12] A.K. SmárasonK.G. AllmanD. YoungC.W. Redman, Br. J. Obstet. Gynaecol., 1997, 104, 538-543. [Crossref], [Google Scholar], [Publisher
[13] N.W. Tietz, Clinical Guide to Laboratory Tests, W.B. Saunders Company, Philadelphia, 1995, 22-23. [Google Scholar], [Publisher
[14] F.J. Almeida, C.R. Lopes, M.V. Arnoni, E.N. Berezin, Braz J. Infect. Dis., 2007, 11, 375-377.
[15] U.R. Goonetilleke, mBio, 2012, 3, e00272-11. [Crossref], [Google Scholar], [Publisher]
[16] E.R. Sarhat, A.H. Alanee, A.R. Sarhat, Y.A.M. Al-Noaemi, J.F. Al Dahhan,  Tikrit Med. J., 2007, 13, 102-105. [Google Scholar], [Publisher]
[17] A. Jha, N.C. Dwivedi, S.K. Verma, A.K. Chaurasia, Int. J. Adv. Med., 2017, 4, 824-829. [Crossref], [Google Scholar], [Publisher]
[18] T. Barichello, I. dos Santos, G.D. Savi, J. Neuroimmunol., 2010, 221, 42–45. [Crossref], [Google Scholar], [Publisher]
[19] T. Barichello, J.S. Generoso, C. Silvestre, Eur. J. Clin. Microbiol. Infect. Dis., 2012, 31, 2005–2009. [Crossref], [Google Scholar], [Publisher]
[20] I.J. Mohammed, E.R. Sarhat, M.A. Hamied, T.R. Sarhat, Sys. Rev. Pharm., 2021, 12, 55-59. [Google Scholar], [Publisher]
[21] D. Miric, R. Katanic, B. Kisic, Clin. Biochem., 2010, 43, 246–252. [Crossref], [Google Scholar], [Publisher]
[22] M. Ramakrishnan, A. Ulland, L.C. Sreinhardt,BMC Med., 2009, 7, 47. [Crossref], [Google Scholar], [Publisher]
[23] E.R. Sarhat, S.A. Wadi, A.R. Mahmood, Res. J. Pharm. Tech., 2018, 11, 4601-4604. [Crossref], [Google Scholar], [Publisher]
[24] S.A. Hamed, E.A. Hamed, M.M. Zakary, BMC Neurol., 2009, 9, 51. [Crossref], [Google Scholar], [Publisher]
[25] B.I. Sedeeq, E.R. Sarhat, S.A. Wadee, T.R. Sarhat, K.S. Abass, Indian J. Forensic Med. Toxicol., 2021, 15, 2127-2135. [Google Scholar], [Publisher]
[26] F. Romero, M. Pérez, M. Chávez, G. Parra, P. Durante, Basic Clin. Pharmacol. Toxicol., 2009, 105, 416–424. [Crossref], [Google Scholar], [Publisher]
[27] G.L. Bowman, J. Shannon, B. Frei, J.A. Kaye, J.F. Quinn, J. Alzheimers Dis., 2010, 19, 1331–1336. [Crossref], [Google Scholar], [Publisher]
[28] D.C. Hooper, G.S. Scott, A. Zborek, T. Mikheeva, R.B. Kean, H. Koprowski, , FASEB J., 2000, 14, 691–698. [Crossref], [Google Scholar], [Publisher]
[29] P. Fang, X. Li, J.J. Luo, H. Wang, X. Yang, Brain Disord. Ther., 2013, 2, 109. [Crossref], [Google Scholar], [Publisher]
[30] J. Liu, F. Tan, M. Li, H. Yi, L. Xu, X. Wang, X.F. Zhong, F.H. Peng, Neurol-Neuroimmunol., 2016, 3, 262-267. [Crossref], [Google Scholar], [Publisher]
[31] M. Bernardi, C.S. Ricci, G. Zaccherini, J. Clin. Exp. Hepatol., 2014, 4, 302-311. [Crossref], [Google Scholar], [Publisher]
[32] C. Nascimento-Carvalho, O.A. Moreno-Carvalho, Arq. Neuro-Psiquiatr., 1998, 56, 375-380. [Crossref], [Google Scholar], [Publisher]
[33] Najamuddin, S.R. Jaffar, F. Sana, N. Magsi, Pakistan J. Medical Health Sci., 2017, 11, 61-63. [Crossref], [Google Scholar], [Publisher]
[34] J. Munoz-Sanchez, M.E. Chanez-Cardenas, Oxid. Med. Cell. Longev., 2014, 2014. [Crossref], [Google Scholar], [Publisher]
[35] E.R. Sarhat, T.R. Sarhat, D.N. Tawfeeq, Eur. Acad. Res., 2016, 4, 112-131. [Google Scholar], [Publisher]
[36] B.L. Buster, A.C. Weintrob, G.C. Townsend, W.M. Scheld, Infect. Immun., 1995, 63, 3835–3839. [Crossref], [Google Scholar], [Publisher]
[37] E. Murawska-Ciałowicz, Z. Szychowska, B. Trębusiewicz, Int. J. Clin. Lab. Res., 2000, 30, 127-131. [Crossref], [Google Scholar], [Publisher]
[38] H. Tsukahara, T. Haruta, N. Ono, R. Kobata, Y. Fukumoto, M. Hiraoka, M. Mayumi. Redox Rep., 2000, 5, 295-298. [Crossref], [Google Scholar], [Publisher]
[39] E.R. Sarhat, I.J. Mohammed, N.Y. Mohammed, B.S. Khairy, F.F. Hassan. Tikrit Journal for Dental Sciences, 2019, 7, 20-26. [Google Scholar], [Publisher]
[40] R. Rodrigo, J.C. Prieto, R. Aguayo, C. Ramos, Á. Puentes, A. Gajardo, E. Panieri, C. Rojas-Solé, J. Lillo-Moya, L. Saso, Molecules, 2021, 26, 5702. [Crossref], [Google Scholar], [Publisher]
[41] E.R. Sarhat, A.R. Sarhat, Z.N. Mustafa, S.A. Wadi. Tikrit Journal for Dental Sciences, 2019, 7, 27-30.  [Google Scholar], [Publisher]
[42] A.Q. Hamdi, E.R. Sarhat, N.H. Ali, T.R. Sarhat, Indian J. Forensic Med. Toxicol., 2021, 15, 1668-1674. [Google Scholar], [Publisher]
[43] A. Aycicek, A. Iscan, O. Erel, M. Akcali, Pediatr. Neurol., 2006, 35, 382–386. [Crossref], [Google Scholar], [Publisher]
[44] I.A.J. Thanoon, M.M. Khalaf, M.K. Oglah, Malays. J. Pharm. Sci., 2009, 7, 73–81. [Google Scholar], [Publisher]
[45] I. Stojanović, S. Ljubisavljević, I. Stevanović, S. Stojnev, R. Pavlović, D. Sokolović, A. Petrović, D. Pavlović, T. Cvetković,, 2014, 31, 233-243. [Crossref], [Google Scholar], [Publisher]