Web of Science (Emerging Sources Citation Index), Scopus, ISC

Document Type : Original Research Article


Department of Chemistry, Collage of Education for pure Sciences Ibn AL Haitham University of Baghdad, Baghdad, Iraq


The study aimed to determine the values of the created serum irisin, which plays in hypothyroid patients with type 2 diabetes. In this research, based on the inclusion and exclusion criteria, a total of 60 patients with type 2 diabetes patients with hypothyroidism were chosen as the case group, with a 1:1 ratio which was determined based on the patients’ inclusion rate. The adults in the age range of 30 to 60 were included in this cohort, which was formed at the Medical City/ Baghdad Teaching Hospital. A control group of 60 healthy volunteers of the same gender and age served as the study’s control group. The clinical data was collected on the participants to determine their medical history, hemoglobin (HbA1c), serum hormones T3, T4, TSH, serum AST, ALT, and serum lipids. An enzyme-linked immunosorbent test was used to measure the amount of irisin of the blood (ELISA). The data was analyzed using SPSS 23.0 software and compared between both groups. In total, the single factor analysis revealed that the level of irisin in the T2DM with the hypothyroidism group was significantly greater than in the control group (14.445±3.008 ng/mL vs. 4.121±0.308 ng/mL). The T2DM with hypothyroidism group had higher levels of HbA1c, serum hormone TSH, serum AST, ALT, total cholesterol (TC), and triglyceride (TG) than the control group. The blood irisin levels were greater in the T2DM with Hypothyroidism group than in the control group.

Graphical Abstract

The role of Irisin level hormone and some biochemical parameters in Iraqi diabetic type 2 with hypothyroidism


Main Subjects

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