Web of Science (Emerging Sources Citation Index), ISC

Document Type : Review Article

Authors

1 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

2 Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

3 Department of Endodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran

4 Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

5 Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

6 Deputy of Food and Drug Administration, Urmia University of Medical Sciences, Urmia, Iran

7 Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran

8 Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran

10.22034/ecc.2022.319668.1278

Abstract

The main goal of this study was to gather the most critical bioactivities of curcumin, followed by the most essential concerns in its clinical usage and the challenges and potential for its use in modern medical studies. The conducted clinical studies on curcumin showed an effective anti-inflammatory and anti-cancer agent. The search results also revealed that curcumin has poor systemic bioavailability. Then, designing new methods to improve its bioavailability has always been interesting. Other conditions, such as neurodegenerative disease, cardiovascular disease, and diabetes, should be the subject of additional clinical research in the future. Besides, new procedures, such as adjuvants, drug delivery systems, and structural changes should be used in clinical trials of curcumin.

Graphical Abstract

The most important consideration in clinical usage of curcumin

Keywords

Main Subjects

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